Lambert-Eaton Myasthenic Syndrome (LES)

Prednisone and Azathioprine Medication Corticosteroids and 3, 4-diaminopyridine are used in treatment of LEMS with limited success. The muscle weakness of Lambert-Eaton will improve as the cancer treatment progresses in some cases. If cancer is present, treatment should focus on cancer therapy. Treatment is directed at decreasing the autoimmune response or improving the transmission of the disrupted electrical impulses. Therapy is best coordinated with the primary care physician and appropriate consultants. Fever, muscle weakness may increase with hot weather, or illness use of hot tubs or hot showers. Immunosuppressive drugs such as prednisone and azathioprine can be used to reduce the autoimmune response and lessen symptoms in individuals with the syndrome but without cancer. Steroids and immunosuppressive agents have not been tested in randomized controlled trials other possible treatments such as plasma replace. After the immunosuppressive drugs prednisolone and azathioprine w