Lambert-Eaton Myasthenic Syndrome (LES)

Living with Lambert- Eaton Myasthenic Syndrome  Booklet Information available to download . HERE!

Medications and Myasthenia Gravis  (A Reference for Health Care Professionals) 46 PAGE REFERENCE HERE! Medications and Myasthenia Gravis (A Reference for Health Care Professionals) Copyright © 2000 by Myasthenia Gravis Foundation of America.  All rights reserved. Robert M. Pascuzzi, MD Professor and Chairman Department of Neurology Indiana University School of Medicine Correspondence: Robert M. Pascuzzi, MD Department of Neurology Emerson Hall 125 545 Barnhill Drive Indiana University School of Medicine Indianapolis, IN  46202  USA Telephone:  317/274-4455 E-mail:  rpascuzz@iupui.edu Prepared by the Professional and Public Information Committee Myasthenia Gravis Foundation of America October, 2000 Most recent revision January 2007

Prednisone and Azathioprine Medication Corticosteroids and 3, 4-diaminopyridine are used in treatment of LEMS with limited success. The muscle weakness of Lambert-Eaton will improve as the cancer treatment progresses in some cases. If cancer is present, treatment should focus on cancer therapy. Treatment is directed at decreasing the autoimmune response or improving the transmission of the disrupted electrical impulses. Therapy is best coordinated with the primary care physician and appropriate consultants. Fever, muscle weakness may increase with hot weather, or illness use of hot tubs or hot showers. Immunosuppressive drugs such as prednisone and azathioprine can be used to reduce the autoimmune response and lessen symptoms in individuals with the syndrome but without cancer. Steroids and immunosuppressive agents have not been tested in randomized controlled trials other possible treatments such as plasma replace. After the immunosuppressive drugs prednisolone and azathioprine w

Update on treatment options for Lambert–Eaton myasthenic syndrome: focus on use of amifampridine.   Published online 2011 May 30  Abstract The mainstay of treatment for LEMS is symptomatic but immunotherapy is needed in more severely affected patients. 3, thereby prolonging the action potential and increasing presynaptic calcium concentrations 4-DAP blocks presynaptic potassium channels. 4-DAP for increasing muscle strength and resting compound muscle action potentials has been demonstrated by four placebo-controlled trials the efficacy of 3. More than half of the affected patients have associated small cell lung cancer, and thorough screening for an underlying malignancy is crucial. 4-diaminopyridine (3, amifampridine) has been shown to be more effective 4-DAP, 3, while acetylcholinesterase inhibitors were the first drugs to be used for the amelioration of symptoms. The most common serious adverse events are epileptic seizures. 3, 4-DAP is currently the treatment of choice in p

Differences in clinical features between the Lambert-Eaton myasthenic syndrome with and without cancer: an analysis of 227 published cases THIS IS A LINK TO A GREAT FREE ONLINE 56 PAGE E- BOOK TO PRINT OR READ. Link> Here!                https://openaccess.leidenuniv.nl/bitstream/handle/1887/4275/05.pdf?sequence=15

Question: What is the difference between Myasthenia Gravis and Lambert-Eaton syndrome? How do doctors differentiate between the two in diagnosis? Is the treatment similar? Answer: Myasthenia gravis causes muscle weakness that patients usually appreciate becoming significantly worse with activity. Double vision, swallowing and speaking abnormalities, and difficulty walking and using the arms are common symptoms. Lambert-Eaton may produce similar symptoms, but double vision is less common. Muscle aches are more common and patients often have dry mouth. Patients may also have impotence, constipation, impaired sweating, and blurred vision. Myasthenia gravis is caused by antibodies against acetylcholine receptor and compromise the muscle side of the nerve-muscle communication point. Lambert-Eaton syndrome appears to be caused most often by antibodies to calcium channels of the nerve. Lambert-Eaton is often triggered by the development of a lung cancer. An EMG test can differentiate

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In November 2002, an international group of neurologists interested in the field of paraneoplastic syndromes (PNS) established the PNS Euronetwork supported by a grant from the European Union. The aim is to assist neurologists in the diagnosis and classification of Paraneoplastic symptoms by providing rigorous diagnostic criteria for the different conditions, to interchange information among the different centres, and to facilitate the pooling of patients for clinical trials.   This site contains a section on LEMS under paraneoplastic syndromes of the neuromuscular junction and muscle www.pnseuronet.org

Lambert-Eaton Myasthenic Syndrome (LES) WELCOME! We are a family affected with this personally at first we searched the web for information and links on this with lots of dead ends and leads to scams.  So in turn I dedicated this blog to help others like us!   Please let us know if a link is down and we will remove it.  On behalf of my Family and my Mother welcome and feel free to contribute!                   Lambert Eaton Myasthenic Syndrome part 1 & 2 Great informative videos on LEMS    Its hard to explain to people. But this video is on of the best i have seen!