Lambert-Eaton Myasthenic Syndrome (LES)

 On COVID-19: And LEMS Cancer patients and caregivers share their current life realities.   “I feel overwhelmed with uncertainty, fear, shock, worry, anxiety, sadness, and grief – similar to how I felt when I found out about my daughter’s cancer diagnosis.” This honest response to the influx of news and conversations surrounding the coronavirus outbreak comes from Joan, whose daughter Sarah is currently in maintenance care for optical glioma bilateral. What’s more, Joan is temporarily out of work because of the ongoing crisis, yet another similarity to when she left her job to be by Sarah’s side during treatment. From emotional distress to temporary losses in income, the parallels between living with cancer and navigating this global pandemic are undeniable. COVID-19 is also taking an especially harsh toll on those who are already vulnerable, and we recognize that the financial barriers and health concerns of cancer are only compounded by the spread of the virus. Cancer won’t ...

  How Patients with Cancer, and Survivors, Can Manage Stress Through COVID-19 Uncertainty.   The recent and rapidly evolving developments surrounding the novel coronavirus — also known as COVID-19 – has led to significant uncertainties around the world. Those unknowns have led to panic and have subsequently increased the anxiety and stress some may be feeling, particularly those who have survived cancer or are currently in treatment. “Fear is a natural human emotion. We all have fear during this pandemic, yet the higher risk for health complications from COVID-19 may heighten the stress faced by individuals with cancer. We all need to focus on actions we can take to reduce our risk of contracting the virus, such as social distancing. We can also take practical steps to cope adaptively with chronic stress because the fear is probably not going away anytime soon,” Dr. Shelley Johns, a researcher with the Indiana University Melvin and Bren Simon Comprehensive Cancer Center, said ...

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 <script data-ad-client="ca-pub-3487722702377998" async src="https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js"></script> Tips for Dealing With Pain When You Have LEMS What causes pain in LEMS? In LEMS, the immune system mistakenly attacks nerve cell endings where they meet muscle cells. This impedes the transmission of electrical impulses from the nerve cells to the muscle cells. Over time, they waste away due to inactivity, causing pain. Where does it hurt? Arm and leg movements are affected in LEMS. People with the disorder may find it difficult to walk, get up from a chair, climb steps, or exit a car. Although the levels of severity vary, LEMS patients commonly experience pain in their lower limbs, including the thighs, and in the lower back. Your muscles may ache and become tender. In some cases, simple exertion can cause this. Pain treatments Doctors usually address pain and improper gait — a person’s ...

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Amifampridine, CAS# 54-96-6 is the first and only approved drug thus far for the symptomatic treatment of Lambert-Eaton Myasthenic Syndrome in adults. As a rare autoimmune disease, Lambert-Eaton Myasthenic Syndrome, also called LEMS, is typically caused by  auto antibodies  to voltage gated calcium channels, leading to a reduction in the amount of acetylcholine released from nerve terminals in patients. The predominant symptom of LEMS is muscle weakness, with this weakness usually concentrated in the proximal muscles of the legs and trunk. Additional, devastating symptoms of this rare disease include extreme fatigue, reduced reflexes, drooping of the eyelids, problems with swallowing,

In November 2002, an international group of neurologists interested in the field of paraneoplastic syndromes (PNS) established the PNS Euronetwork supported by a grant from the European Union. The aim is to assist neurologists in the diagnosis and classification of Paraneoplastic symptoms by providing rigorous diagnostic criteria for the different conditions, to interchange information among the different centres, and to facilitate the pooling of patients for clinical trials.   This site contains a section on LEMS under paraneoplastic syndromes of the neuromuscular junction and muscle www.pnseuronet.org